Mechanism of Disease: Immunoglobulin A Nephropathy

The four-hit hypothesis is the prevailing framework of immunoglobin A nephrology (IgAN) pathogenesis.^1-4 In fact, these four hits drive disease pathogenesis and progression, ultimately causing kidney injury through the deposition of immune complexes in the mesangium.^3,4 Learn more about the four hits of IgAN and how this chronic autoimmune disease can impact patients in this brief video.

References:

1. Wyatt RJ, Julian BA. IgA nephropathy. N Engl J Med. 2013;368(25):2402-2414.
2. Mestecky J, Raska M, Julian BA, et al. IgA nephropathy: molecular mechanisms of the disease. Annu Rev Pathol. 2013;8:217-240.
3. Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22(10):1795-1803.
4. Suzuki H. Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis. Clin Exp Nephrol. 2019;23:26-31.

February 2024 US.UNB.X.24.00004