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The death of a spouse often means the loss of intimacy, companionship and everyday support for older adults. A new study finds that widowhood can have another profound effect: It may accelerate cognitive decline. Investigators from Brigham and Women's Hospital and Massachusetts General Hospital analyzed older, cognitively normal Americans enrolled in the Harvard Aging Brain Study whose marital status and brain β-amyloid levels -- a marker of Alzheimer's disease -- were determined at the beginning of the study. The team found that individuals who were widowed experienced a sharper cognitive decline than their married counterparts, especially among those who had high β-amyloid levels. The study suggests that widowhood may be an important and understudied risk factor for cognitive decline associated with Alzheimer's disease and highlights the need for increased focus on this high-risk population. Findings are published in JAMA Network Open.
"We know that social relationships can be an important buffer against cognitive decline. Being married provides an opportunity for more social engagement and emotional support from a spouse, it expands one's social network and it provides more opportunity for cognitive stimulation. All of these benefits are lost in widowhood. Importantly, loss of a spouse is a highly stressful life event which can have deleterious effects on the brain," said senior author, Dr. Nancy Donovan.
Women are at increased risk for both widowhood and Alzheimer's disease, both of which increase in frequency with age. The study, which included 260 cognitively unimpaired adults ages 62 to 89 -- 153 women and 107 men -- classified its subjects into three groups: married, widowed or unmarried (divorced, single, separated or never married). Of these subjects, 66 women and 79 men were married; 31 women and four men were widowed. The researchers measured the subjects' β-amyloid levels using PET scans at the beginning of the study.
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