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Dr. Shafirstein is a Member/Professor of Oncology in the Department of Cell Stress Biology, and the Director of Photodynamic Therapy (PDT) Clinical Research at Roswell Park Cancer Institute. He is a materials scientist who is focused on the development of laser and thermal ablation devices and techniques for the treatment of cancerous tumors.

Working in Roswell Park's PDT Center, Dr. Shafirstein's goal is to expand the use and enhance the translation of PDT. His research team invented and created real-time light dosimetry and treatment planning systems for PDT, which support three clinical studies at the PDT Center.

He is also the co-leader of the clinical project of the PDT-PPG and serves as Director of the PDT Clinical Research Team, providing support for all light base diagnostic and treatment protocols at Roswell Park.