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Dr. Louis H. Philipson is a Professor of Endocrinology in the Department of Medicine of the University of Chicago Medical Center. He also serves on the Committee on Cell Physiology. Dr. Philipson's research focuses on how pancreatic Beta-cells "know" when to secrete insulin and define defects in this process in diabetes that could be therapeutic targets. His focus is the study of ion channels, metabolism, and mitochondria that together regulate intracellular calcium concentration and energy production and thereby regulate insulin secretion in pancreatic islet Beta-cells. He studies such processes as exocytosis of single insulin granules and production of reactive oxygen species in normal and diabetic mice and in human islets.