Prostate cancer is the third leading cause of cancer death in men in the United States, accounting for 8% of all cancer deaths with an estimated 26,730 deaths in 2017. The recent development of novel hormonal agents, chemotherapy, and immunotherapy has dramatically changed the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC). Until 2010, docetaxel was the only agent approved by the US Food and Drug Administration (FDA) to treat mCRPC. Sipuleucel-T and cabazitaxel were both FDA approved in 2010, followed by abiraterone acetate in 2011, enzalutamide in 2012, and most recently, radium-223 dichloride in 2013. With the approval of several new agents by the FDA in recent years, there are now multiple treatment options for patients with mCRPC, making clinical decision-making more difficult. There are also guideline recommendations published from the NCCN, American Urological Association (AUA), and American Society of Clinical Oncology (ASCO), which can contribute to variations in treatment approaches.
Additionally, treatment in an outpatient, office-based setting may result in cost savings compared to both hospital inpatient and outpatient settings. Other advantages include safe and easy drug administration, avoidance of hospitalization, familiarity with a particular facility, enhanced physical comfort, and improved psychological well being.
This activity will review available therapies for mCRPC, selecting and sequencing individualized therapy, treatment guidelines, and considerations for treatment.