As the United States population ages, an increasing number of individuals will suffer from significant pain as they approach end of life.1 Despite advances in our understanding of pain physiology and available treatment modalities, pain associated with life-threatening illnesses is often untreated or undertreated.2 This results in part from side effects of commonly prescribed analgesics. For example, opioids have long been the cornerstone treatment for pain associated with cancer or other terminal conditions.3,4 The most frequent side effect of prescription opioids is constipation, which ranks as the third most commonly reported symptom in palliative care.5,6 Unaddressed opioid-induced constipation (OIC) can have markedly deleterious effects on patient function and quality of life.7,8 With an overall goal of improving comprehensive pain management in patients receiving palliative care, this Evidence-Based Best Practices program will examine the pathophysiology of opioid-induced bowel dysfunction, prophylactic treatment regimens for OIC, assessment strategies to identify and monitor affected patients, and new therapeutic approaches that mitigate OIC effectively and safely.
- Robinson CL. Health Prog. 2007;88(1):48-53.
- Deandrea S, et al. Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol. 2008;19(12):1985-1991.
- National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Adult Cancer Pain. Version 2.2016.
- American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. J Am Geriatr Soc. 2009;57(8):1331-1346.
- Coyne KS, et al. Clinicoecon Outcomes Res. 2014;6:269-281.
- Gatti A, Sabato AF. Clin Drug Investig. 2012;32(5):293-301.
- Holzer P. Expert Opin Investig Drugs. 2007;16(2):181-194.
- Rao SS. Gastroenterol Clin North Am. 2007;36(3):687-711.
Fee Information & Refund/Cancellation Policy
There is no fee for this educational activity.