Insomnia and Comorbidity: High Risk with Poor Outcomes

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Insomnia and Comorbidity: High Risk with Poor Outcomes

Insomnia and Comorbidity: High Risk with Poor Outcomes
Insomnia is one of the most common sleep disturbances with significant negative impacts on patients' everyday functioning and quality of life.

Available credits: 0.75

Time to complete: 45 minutes


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  • Overview

    Insomnia is one of the most common sleep disturbances with significant negative impacts on patients' everyday functioning and quality of life.  Patients with chronic insomnia are more likely to develop affective disorders, cardiac morbidity, and other adverse health outcomes, yet it is under-recognized and under treated.

    This case-based CME activity “Insomnia and Comorbidity High Risk with Poor Outcomes” will take clinicians through several patients journeys to examine the relationships between insomnia and common comorbidities including cardiovascular disease, diabetes and psychiatric disorders. Clinicians will apply the latest understanding of the pathophysiology of sleep and wake disorders to individualize the management of each patient, using a variety of approaches including newer agents such as orexin antagonist, melatonin receptor agonist, sedating antidepressant or benzodiazepine.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Commercial Support, The Omnia-Prova Education Collaborative (TOPEC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TOPEC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Larry Culpepper, MD, MPH
    Professor of Family Medicine
    Boston University School of Medicine

    Faculty’s disclosure

    Dr. Larry Culpepper, has disclosed that he receives consulting fees from Alkermes, Lundbeck AS, In., Merck, Sunovion Pharm, Inc.  He receives royalties from UpToDate and Oxford University Press.  He owns stock in My Mood Monitor, Inc. (M3).  He is Editor in Chief of the Primary Care Companion for CNS Disease of the Physicians Postgraduate Press


    • Carole Drexel, PhD CHCP has nothing to disclose.
    • Kia K. Gray, MPH has nothing to disclose.
    • Nick Lombardi has nothing to disclose.
    • Jessica McGrory nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Understand the pathogenesis of insomnia and its burden of disease
    • Describe the interplay between insomnia and chronic disease
    • Understand individualized short and long-term treatment planning approaches
    • Understand the mechanisms of action of pharmacologic agents that address the pathophysiology of insomnia, especially in those over 40, being treated with multiple drugs for comorbid diseases
  • Target Audience

    This activity is designed to meet the educational needs of obstetricians, gynecologists, primary care physicians, nurse practitioners, physician assistants, and certified nurse midwives.

  • Accreditation and Credit Designation Statements

    The Omnia-Prova Education Collaborative, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    The Omnia-Prova Education Collaborative, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider

    Prova Education designs educational activities based on evidence-based medicine, needs and gaps analyses, learner feedback, and more. Its mission is to serve as an innovative and relevant resource for clinical content and educational interventions across a broad spectrum of specialties.

  • Commercial Support

    This activity is supported by an independent educational grant from Merck.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of TOPEC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited

    Reproduction of this material is not permitted without written permission from the copyright owner.

  • System Requirements

    Our site requires a computer, tablet or mobile device and a connection to the Internet. For best results, a high-speed Internet connection is recommended (DSL/cable). We also recommend using the latest version of your favorite browser to ensure compliance with W3C standards, such as Internet Explorer, Microsoft Edge, Chrome, Firefox or Safari. Users accustomed to IE8, IE9 IE10 are advised to update their browsers for the best experience.

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