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This medical industry feature, titled “Pathophysiology of Obstructive Sleep Apnea & Its Role in Excessive Daytime Sleepiness” is provided in partnership with Jazz Pharmaceuticals, Inc. This program is intended for physicians.
Here’s Dr. Richard Bogan, Associate Clinical Professor at the University of South Carolina School of Medicine and Chairman and Chief Medical Officer at SleepMed, Incorporated.
Dr. Bogan is a paid consultant for Jazz Pharmaceuticals, Inc.
Dr. Bogan: Researchers continue to learn more about excessive sleepiness in obstructive sleep apnea or OSA.
Many factors, such as insufficient sleep, medication, or comorbid sleep disorders, can cause your patients with OSA to feel sleepy.
Recent studies have identified new findings about the potential consequences of OSA, including physiologic changes to the brain occurring as a result of chronic sleep disruption and chronic intermittent hypoxia.
Clinical and animal studies have suggested that sleep fragmentation and chronic intermittent hypoxia are associated with injury to wake-promoting neurons in the brain.
In one study involving a mouse model of chronic sleep fragmentation, data show that neuronal injury can occur when sleep is disrupted. Specifically, this research looked at the effect of chronic sleep disruption on wake neuron survival in 8-week-old male mice.
The data revealed that 14 weeks of chronic sleep fragmentation caused an approximate 50% reduction in the total number of noradrenergic neurons in the locus coeruleus and reduced dendrite projections in these wake-promoting neurons.
These effects were observed even after 4 weeks of normal sleep/wake conditions in mice.
In a different study of chronic intermittent hypoxia, the long-term intermittent hypoxia protocol was used in adult mice to model sleep apnea oxygenation patterns observed in patients with severe OSA. As compared with sham controls, 6-month exposure to hypoxia and subsequent reoxygenation resulted in a 40% loss of wake-active dopaminergic and noradrenergic neurons in the ventrolateral periaqueductal gray and locus coeruleus regions.
However, other wake-active neural groups, such as monoaminergic, cholinergic, and orexinergic neurons, were spared from injury.
The animal data tell us that OSA-associated chronic sleep fragmentation and intermittent hypoxia can result in injury to wake-promoting neurons, potentially resulting in excessive sleepiness.
Imaging studies in humans have also shown changes to brain physiology including white matter and gray matter.
In individuals with untreated OSA, changes in brain anatomy include a reduction in gray matter concentration in certain regions of the brain. Affected areas include the thalamus, anterior cingulate cortex, and frontal cortex.
These areas are involved in wakefulness and neurocognitive performance, such as those that mediate attention and higher-order cognitive processes—for example, executive functions.
White matter, which refers to myelinated neuronal pathways, also can be affected by OSA. Consider another recent study.
Diffusion tensor imaging was used to evaluate white matter neuronal tracts in patients who were adherent to CPAP for 6 or more hours per night for 30 days. One group had ongoing sleepiness while the other group did not.
The data indicate that whole brain mean diffusivity was significantly higher in the sleepy group compared with the nonsleepy group—a factor that indicates widespread changes in white matter.
Results do suggest that patients with OSA and sleepiness have altered white matter density compared with nonsleepy patients with OSA.
What we can conclude from the research is that excessive sleepiness is associated with structural changes to brain white matter.
This indicates that neuronal connectivity in patients with OSA who experience excessive sleepiness, may be compromised.
We continue to learn more about the pathophysiology and challenges of excessive sleepiness in OSA.
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References:
Chapman JL, Serinel Y, Marshall NS, Grunstein RR. Residual daytime sleepiness in obstructive sleep apnea after continuous positive airway pressure optimization: causes and management. Sleep Med Clin. 2016;11(3):353-363.
Zhou J, Camacho M, Tang X, Kushida CA. A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness. Sleep Med. 2016;23:99-108.
Zhu Y, Fenik P, Zhan G, Xin R, Veasey SC. Degeneration in arousal neurons in chronic sleep disruption modeling sleep apnea. Front Neurol. 2015;6:109.
Zhu Y, Fenik P, Zhan G, et al. Selective loss of catecholaminergic wake–active neurons in a murine sleep apnea model. J Neurosci. 2007;27(37):10060-10071.
Veasey SC, Davis CW, Fenik P, et al. Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. Sleep. 2004;27(2):194-201.
Li Y, Panossian LA, Zhang J, et al. Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response. Sleep. 2014;37(1):51-64.
Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep. 2010;33(2):235-241.
Xiong Y, Zhou XJ, Nisi RA, et al. Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness. J Magn Reson Imaging. 2017;45(5):1371-1378.
Lal C, Strange C, Bachman D. Neurocognitive impairment in obstructive sleep apnea. Chest. 2012;141(6):1601-1610.
Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res. 2002;11(1):1-16.
Wimmer RD, Schmitt LI, Davidson TJ, Nakajima M, Deisseroth K, Halassa MM. Thalamic control of sensory selection in divided attention. Nature. 2015;526(7575):705-709.
Davis KD, Hutchison WD, Lozano AM, Tasker RR, Dostrovsky JO. Human anterior cingulate cortex neurons modulated by attention-demanding tasks. J Neurophysiol. 2000;83(6):3575-3577.
España RA, Scammell TE. Sleep neurobiology from a clinical perspective. Sleep. 2011;34(7):845-858.
Gompf HS, Mathai C, Fuller PM, et al. Locus coeruleus (LC) and anterior cingulate cortex sustain wakefulness in a novel environment. J Neurosci. 2010;30(43):14543-14551.
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