Bisphosphonates were the first class of drugs to be approved for the treatment of osteoporosis, and they remain the foundation of treatment to this day. What is it about this class that makes it so efficacious—and what are some of the pitfalls? Host Dr. John Russell welcomes Sol Epstein, MD, FRCP, FACP, professor of medicine and geriatrics at Mt. Sinai School of Medicine in New York, and adjunct professor of medicine at the University of Pennsylvania. Dr. Epstein is currently a paid consultant to Mission Pharmacal Company.